KCNJ11 and ABCC9

Data Source:
HPRD (in vitro)

		KCNJ11	ABCC9
Description		potassium inwardly rectifying channel subfamily J member 11	ATP binding cassette subfamily C member 9
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Plasma Membrane Inward Rectifying Potassium Channel Membrane Sarcomere Potassium Ion-transporting ATPase Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding	Cation Channel Activity Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding
	Biological Process	Response To Ischemia Glucose Metabolic Process Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Transmembrane Transport Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity	Response To ATP Defense Response To Virus Transmembrane Transport Cardiac Conduction Potassium Ion Transmembrane Transport Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Across Blood-brain Barrier Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	ATP Glyburide Nicorandil
Diseases		Type II diabetes mellitus Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)	Atrial fibrillation
GWAS		Body mass index ( 26426971 28892062 25673413 29273807) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 32499647 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)	Appendicular lean mass ( 33097823) Birth weight ( 27680694) Gout ( 22179738) Hippocampal sclerosis of aging ( 24770881) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	6 interacting genes: EEF1G HSPB2 KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3767	10060
HPRD ID		09022	03258
Ensembl ID		ENSG00000187486	ENSG00000069431
Uniprot IDs		B2RC52 Q14654	A0A024RAV7 O60706
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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