KCNJ5 and KCNJ3

Data Source:
HPRD (in vivo, in vitro)

		KCNJ5	KCNJ3
Description		potassium inwardly rectifying channel subfamily J member 5	potassium inwardly rectifying channel subfamily J member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex External Side Of Plasma Membrane T-tubule	Plasma Membrane Voltage-gated Potassium Channel Complex External Side Of Plasma Membrane T-tubule Parallel Fiber To Purkinje Cell Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Import Across Plasma Membrane	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Response To Electrical Stimulus Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ethanol Ifenprodil	Atomoxetine Ethanol Halothane B-nonylglucoside Dronedarone Ifenprodil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive error ( 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Age at voice drop ( 27182965) Alcoholic chronic pancreatitis ( 28754779) Automobile speeding propensity ( 30643258) Dentures ( 31235808) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Feeling miserable ( 29500382) General cognitive ability ( 29844566) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 24871463)
Interacting Genes		3 interacting genes: ADRB2 KCNJ15 KCNJ3	4 interacting genes: GNB1 KCNJ5 KCNJ6 KCNJ9
Entrez ID		3762	3760
HPRD ID		09010	03323
Ensembl ID		ENSG00000120457	ENSG00000162989
Uniprot IDs		A0A5J6E2W8 P48544	D2X9V0 D2XBF0 P48549
PDB IDs
Enriched GO Terms of Interacting Partners?
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