KCNJ2 and KCNJ8

Data Source:
HPRD (in vivo, in vitro)

		KCNJ2	KCNJ8
Description		potassium inwardly rectifying channel subfamily J member 2	potassium inwardly rectifying channel subfamily J member 8
Image			No pdb structure
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Myofibril Potassium Ion-transporting ATPase Complex Sarcolemma
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Cation Transmembrane Transporter Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Regulation Of Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cardiac Conduction Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Kidney Development Potassium Ion Transport Heart Development Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Response To Exogenous DsRNA Defense Response To Virus Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	ATP sensitive Potassium channels
Drugs		Ranolazine Miconazole Carvedilol Dronedarone	Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome Andersen-Tawil syndrome (ATS)
GWAS		Adolescent idiopathic scoliosis (severe) ( 24023777) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Chin dimples ( 27182965) Dentures ( 31235808) Depressive episodes in bipolar disorder ( 26297903) Early cardiac repolarization ( 22342860) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Formal thought disorder in schizophrenia ( 22648509) HDL cholesterol levels ( 32203549 32109663) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Macular thickness ( 30535121) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Prudent dietary pattern ( 28644415) Pulmonary function (smoking interaction) ( 23284291) QT interval ( 30679814 24952745 19305409 29874175) Refractive error ( 23396134) Renal overload gout ( 32238385) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) TPE interval (response to exercise) ( 32386560) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Birth weight ( 31043758)
Interacting Genes		20 interacting genes: AKAP5 ARL13B CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ15 KCNJ16 KCNJ18 KCNJ4 KCNJ8 PATJ SDC3 SDCBP SEC22A TRAK2	7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54
Entrez ID		3759	3764
HPRD ID		02815	02962
Ensembl ID		ENSG00000123700	ENSG00000121361
Uniprot IDs		P63252	A0A024RAV6 Q15842
PDB IDs		6SPZ
Enriched GO Terms of Interacting Partners?
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