AGRN and ATN1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AGRN	ATN1
Description		agrin	atrophin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Golgi Lumen Plasma Membrane Integral Component Of Membrane Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Dystroglycan Binding Structural Constituent Of Cytoskeleton Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding	RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cytoskeleton Organization Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Junction Development Animal Organ Morphogenesis Tissue Development Extracellular Matrix Organization Receptor Clustering Positive Regulation Of GTPase Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Positive Regulation Of Filopodium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Neuron Apoptotic Process
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Regulation of PTEN gene transcription
Drugs
Diseases		Congenital myasthenic syndrome	Dentatorubropallidoluysian atrophy (DRPLA)
GWAS			Refractive error ( 32231278)
Interacting Genes		9 interacting genes: ATN1 ATXN7 BOLL CACNA1A DAG1 GFI1B MAGED1 TEPSIN UBC	121 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PPP1R32 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SH3RF1 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 USP2 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZNF503 ZSWIM8
Entrez ID		375790	1822
HPRD ID		10550	06311
Ensembl ID		ENSG00000188157	ENSG00000111676
Uniprot IDs		O00468	P54259 Q86V38
PDB IDs
Enriched GO Terms of Interacting Partners?
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