VEGFD and ITGA9

Data Source:
HPRD (in vivo, in vitro)

		VEGFD	ITGA9
Description		vascular endothelial growth factor D	integrin subunit alpha 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Plasma Membrane Integrin Complex Integrin Alpha9-beta1 Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 3 Binding	Collagen Binding Laminin Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Platelet Degranulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Bacterium Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Dopaminergic Neuron Differentiation	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Wound Healing
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1
Drugs
Diseases		Gastric cancer	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-herpes simplex virus 6 IE1A IgG seropositivity ( 33204752) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Mortality in sepsis ( 27639821) Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) Platelet count ( 32888494) PR interval ( 23139255) Pulse pressure ( 30224653 30578418) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: FLT4 ITGA9 KDR VAMP3	6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD
Entrez ID		2277	3680
HPRD ID		02102	04910
Ensembl ID		ENSG00000165197	ENSG00000144668
Uniprot IDs		O43915	Q13797 Q8N6H6
PDB IDs		2XV7
Enriched GO Terms of Interacting Partners?
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