INHBB and IGSF1

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		INHBB	IGSF1
Description		inhibin subunit beta B	immunoglobulin superfamily member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery	Extracellular Region Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Protein Binding Coreceptor Activity Inhibin Binding Activin Receptor Antagonist Activity
	Biological Process	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Wounding Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Negative Regulation Of Activin Receptor Signaling Pathway
Pathways		Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Urate levels ( 31985003 23263486)	Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)
Interacting Genes		12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 FNTA IGSF1 INHA INHBA INHBC TDGF1	8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		3625	3547
HPRD ID		00934	02138
Ensembl ID		ENSG00000163083	ENSG00000147255
Uniprot IDs		P09529	Q8N6C5
PDB IDs
Enriched GO Terms of Interacting Partners?
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