IGSF1 and HECTD1

		IGSF1	HECTD1
Description		immunoglobulin superfamily member 1	HECT domain E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Coreceptor Activity Inhibin Binding Activin Receptor Antagonist Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Activin Receptor Signaling Pathway	Heart Valve Development Ventricular Septum Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Anatomical Structure Development Protein K63-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)
Interacting Genes		8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	8 interacting genes: HRAS HSPB1 IGSF1 MTNR1B UBE2D2 UBE2D3 UBE2L3 YWHAG
Entrez ID		3547	25831
HPRD ID		02138	17098
Ensembl ID		ENSG00000147255	ENSG00000092148
Uniprot IDs		Q8N6C5	Q9ULT8
PDB IDs			2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?
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