IL1RAP and IL1R2

Data Source:
HPRD (in vivo)

		IL1RAP	IL1R2
Description		interleukin 1 receptor accessory protein	interleukin 1 receptor type 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Immune Response Negative Regulation Of Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Interleukin-1-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways			Interleukin-10 signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)	Ankylosing spondylitis ( 23749187 20062062) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576 29875488) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 28067908 23128233) Parkinson's disease ( 32201043 28892059) Ulcerative colitis ( 21297633)
Interacting Genes		20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15
Entrez ID		3556	7850
HPRD ID		04021	00995
Ensembl ID		ENSG00000196083	ENSG00000115590
Uniprot IDs		A8K6K4 Q9NPH3	P27930
PDB IDs		3O4O 4DEP	3O4O
Enriched GO Terms of Interacting Partners?
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