LCE1A and EFEMP2

Data Source:
BioGRID (two hybrid)

		LCE1A	EFEMP2
Description		late cornified envelope 1A	EGF containing fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity
	Biological Process	Cornification	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways		Formation of the cornified envelope	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Retinal detachment or retinal break ( 31816047)
Interacting Genes		69 interacting genes: ADAMTSL4 AQP1 CCN3 CFP CHIC2 CYSRT1 EFEMP2 FBLN1 FUCA2 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LCE5A MDFI MESD NBPF19 NID2 NOTCH2NLA PLA2G10 PLAC8 PLSCR2 PLSCR4 RGS17 RGS20 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L	130 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837
Entrez ID		353131	30008
HPRD ID		13966	05221
Ensembl ID		ENSG00000186844	ENSG00000172638
Uniprot IDs		Q5T7P2	A0A024R5G1 O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?
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