IGFALS and PDCD6

Data Source:
HPRD (in vivo)

		IGFALS	PDCD6
Description		insulin like growth factor binding protein acid labile subunit	programmed cell death 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Insulin-like Growth Factor Ternary Complex Extracellular Exosome	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Insulin-like Growth Factor Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Cell Adhesion Signal Transduction Cellular Protein Metabolic Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS		Blood protein levels ( 30072576) Insulin-like growth factors ( 21216879) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		4 interacting genes: IGF1 IGFBP3 IGFBP5 PDCD6	22 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 PRR19 SEC31A SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		3483	10016
HPRD ID		03290	03035
Ensembl ID		ENSG00000099769	ENSG00000249915
Uniprot IDs		P35858 Q8TAY0	A0A024QZ42 A0A087WZ38 O75340 Q53FC3
PDB IDs			2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ
Enriched GO Terms of Interacting Partners?
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