PDCD6 and TIMM22

Data Source:
HPRD (in vitro)

		PDCD6	TIMM22
Description		programmed cell death 6	translocase of inner mitochondrial membrane 22
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site	Mitochondrial Inner Membrane Integral Component Of Membrane TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Protein Transporter Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Protein Targeting To Mitochondrion Protein Insertion Into Mitochondrial Inner Membrane Protein Transmembrane Transport
Pathways			Mitochondrial protein import Mitochondrial protein import
Drugs		Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS
Interacting Genes		22 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 PRR19 SEC31A SH3KBP1 TIMM22 VPS37C YWHAQ	4 interacting genes: CYSRT1 PDCD6 REEP4 TMEM14B
Entrez ID		10016	29928
HPRD ID		03035	06262
Ensembl ID		ENSG00000249915	ENSG00000177370
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	Q9Y584
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ	7CGP
Enriched GO Terms of Interacting Partners?
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