IGFBP7 and SDC1

Data Source:
HPRD (in vivo)

		IGFBP7	SDC1
Description		insulin like growth factor binding protein 7	syndecan 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein-containing Complex Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Heat Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Steroid Biosynthetic Process Response To Cortisol	Retinoid Metabolic Process Ureteric Bud Development Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Response To Toxic Substance Cell Migration Cytokine-mediated Signaling Pathway Wound Healing Odontogenesis Response To Hydrogen Peroxide Myoblast Development Leukocyte Migration Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Retinoid metabolism and transport
Drugs		Insulin pork
Diseases
GWAS		Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Body mass index ( 28892062) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Seasonality ( 25562672) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA	16 interacting genes: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTEN PTN SDCBP
Entrez ID		3490	6382
HPRD ID		04183	01718
Ensembl ID		ENSG00000163453	ENSG00000115884
Uniprot IDs		Q16270	P18827
PDB IDs			4GVC 4GVD 6EJE
Enriched GO Terms of Interacting Partners?
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