IFNGR1 and STIM1

Data Source:
BioGRID (two hybrid)

		IFNGR1	STIM1
Description		interferon gamma receptor 1	stromal interaction molecule 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation	Store-operated Calcium Entry Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Cardiac Conduction Regulation Of Store-operated Calcium Entry
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)
Interacting Genes		16 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237	5 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2
Entrez ID		3459	6786
HPRD ID		00127	05803
Ensembl ID		ENSG00000027697	ENSG00000167323
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	G0XQ39 Q13586
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L	2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
Enriched GO Terms of Interacting Partners?
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