STIM1 and STIM2

Data Source:
HPRD (in vivo, in vitro)

		STIM1	STIM2
Description		stromal interaction molecule 1	stromal interaction molecule 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Microtubule Plus-end Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Store-operated Calcium Channel Activity
	Biological Process	Store-operated Calcium Entry Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Cardiac Conduction Regulation Of Store-operated Calcium Entry	Store-operated Calcium Entry Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) Hirschsprung disease ( 25310821) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Refractive astigmatism ( 25367360) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		5 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2	3 interacting genes: CALM1 PRPF40A STIM1
Entrez ID		6786	57620
HPRD ID		05803	11609
Ensembl ID		ENSG00000167323	ENSG00000109689
Uniprot IDs		G0XQ39 Q13586	B3KUB5 Q9P246
PDB IDs		2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL	2L5Y
Enriched GO Terms of Interacting Partners?
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