IFNGR1 and TMEM100

Data Source:
BioGRID (two hybrid)

		IFNGR1	TMEM100
Description		interferon gamma receptor 1	transmembrane protein 100
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Molecular_function Protein Binding
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation	Angiogenesis Vasculogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Notch Signaling Pathway BMP Signaling Pathway Protein Kinase B Signaling Positive Regulation Of Endothelial Cell Differentiation Regulation Of Calcium-mediated Signaling Regulation Of Sensory Perception Of Pain Arterial Endothelial Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Vasculogenesis
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Height ( 22021425) Pulse pressure ( 30578418)
Interacting Genes		16 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237	33 interacting genes: AQP6 CCDC57 CD33 CLDN7 COMT CREB3 EBP ERGIC3 F11R FAM209A FNDC9 GJA8 GPR152 HSD17B13 IFNGR1 JAGN1 LHFPL5 MEOX2 NUP93 REEP1 RETREG3 RMDN3 RNF19B SLC30A4 SLC35A5 STING1 STX1A TMEM130 TMEM167B TMEM52B TMEM79 TMEM80 VSIR
Entrez ID		3459	55273
HPRD ID		00127	07719
Ensembl ID		ENSG00000027697	ENSG00000166292
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	Q9NV29
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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