IFNG and IFNGR1

Data Source:
BioGRID (affinity chromatography technology, x-ray crystallography, pull down)
HPRD (in vitro, in vivo)

		IFNG	IFNGR1
Description		interferon gamma	interferon gamma receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Macrophage Activation Involved In Immune Response Apoptotic Process Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Protein ADP-ribosylation Macrophage Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Nitrogen Compound Metabolic Process Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of Core Promoter Binding Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Olsalazine Glucosamine VIR201 Fontolizumab Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Emapalumab	Interferon gamma-1b
Diseases		Graft-versus-host disease Allograft rejection	Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 20228799 21297633 19122664)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	16 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		3458	3459
HPRD ID		00957	00127
Ensembl ID		ENSG00000111537	ENSG00000027697
Uniprot IDs		P01579	A0A0S2Z3Y2 A0A2R8Y4U4 P15260
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L	1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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