IFNA2 and TIMMDC1

Data Source:
BioGRID (two hybrid)

		IFNA2	TIMMDC1
Description		interferon alpha 2	translocase of inner mitochondrial membrane domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production	Complex I biogenesis
Drugs		Sifalimumab
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)	Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469) Systemic sclerosis ( 31672989)
Interacting Genes		3 interacting genes: IFNAR1 IFNAR2 TIMMDC1	70 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL3 APP ARL6IP6 ATP6AP2 BCAP31 C14orf180 C3orf52 C4orf3 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 KIR2DL4 LHFPL5 MARCHF5 MFSD14B MFSD5 NDUFB11 NINJ1 PEX5 PIGF PTPN1 PTPRN RNF24 SCAMP5 SCD SERF1A SERF1B SERP2 SLC35E4 SLC35F6 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM199 TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UNC93A YIF1A YIPF1
Entrez ID		3440	51300
HPRD ID		00950	12817
Ensembl ID		ENSG00000188379	ENSG00000113845
Uniprot IDs		P01563	C9JU35 Q9NPL8
PDB IDs		1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?
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