IFNA2 and IFNAR1

Data Source:
HPRD (in vivo)

		IFNA2	IFNAR1
Description		interferon alpha 2	interferon alpha and beta receptor subunit 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Sifalimumab	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		3 interacting genes: IFNAR1 IFNAR2 TIMMDC1	25 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3440	3454
HPRD ID		00950	00126
Ensembl ID		ENSG00000188379	ENSG00000142166
Uniprot IDs		P01563	A0A494C0E2 P17181
PDB IDs		1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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