RD3 and EIF2B1

Data Source:
BioGRID (two hybrid, two hybrid)

		RD3	EIF2B1
Description		RD3 regulator of GUCY2D	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Perinuclear Region Of Cytoplasm Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Visual Perception Protein Transport Negative Regulation Of Guanylate Cyclase Activity Response To Stimulus Retina Development In Camera-type Eye	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways			Recycling of eIF2:GDP
Drugs
Diseases		Leber congenital amaurosis (LCR)	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Intelligence (MTAG) ( 29326435) Retinopathy in non-diabetics ( 23393555)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: APP CABP2 EHMT2 EIF2B1 NTAQ1	21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I
Entrez ID		343035	1967
HPRD ID		12726	09458
Ensembl ID		ENSG00000198570	ENSG00000111361
Uniprot IDs		Q7Z3Z2	Q14232
PDB IDs		6DRF	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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