IDH3A and RAB4A

Data Source:
BioGRID (two hybrid)

		IDH3A	RAB4A
Description		isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	RAB4A, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding NAD Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process	Phosphatidylinositol Biosynthetic Process Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity
Pathways		Citric acid cycle (TCA cycle)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs		NADH Manganese Xanthinol Copper
Diseases
GWAS		Eyebrow thickness ( 26926045)	Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		5 interacting genes: IDH3B IDH3G MBNL1 RAB4A SUMO4	33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		3419	5867
HPRD ID		03094	01541
Ensembl ID		ENSG00000166411	ENSG00000168118
Uniprot IDs		B7Z9J8 P50213	A0A024R3U9 A0A087WYT5 P20338
PDB IDs		5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6KDE 6KDF 6KDY 6KE3 6L57 6L59	1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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