IDH3A and SUMO4

Data Source:
HPRD (in vivo)

		IDH3A	SUMO4
Description		isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix	Nucleus SUMO Ligase Complex
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding NAD Binding	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Citric acid cycle (TCA cycle)
Drugs		NADH Manganese Xanthinol Copper
Diseases
GWAS		Eyebrow thickness ( 26926045)	Dupuytren's disease ( 28886342)
Interacting Genes		5 interacting genes: IDH3B IDH3G MBNL1 RAB4A SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3419	387082
HPRD ID		03094	10584
Ensembl ID		ENSG00000166411	ENSG00000177688
Uniprot IDs		B7Z9J8 P50213	Q6EEV6
PDB IDs		5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6KDE 6KDF 6KDY 6KE3 6L57 6L59
Enriched GO Terms of Interacting Partners?
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