IDH2 and GPX1

Data Source:
BioGRID (affinity chromatography technology)

		IDH2	GPX1
Description		isocitrate dehydrogenase (NADP(+)) 2	glutathione peroxidase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP Metabolic Process NADP Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization
Pathways		Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle)	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism
Drugs		Isocitric Acid Enasidenib	Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols
Diseases			Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		3 interacting genes: FBXO7 PYGL SLC2A4	5 interacting genes: ABL1 ABL2 FAM9B MAPK6 SELENBP1
Entrez ID		3418	2876
HPRD ID		00973	11749
Ensembl ID		ENSG00000182054	ENSG00000233276
Uniprot IDs		B4DSZ6 P48735	A0A2R8Y6B6 P07203 Q7L4Q3
PDB IDs		4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6VFZ	2F8A
Enriched GO Terms of Interacting Partners?
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