IDH2

Description		isocitrate dehydrogenase (NADP(+)) 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP Metabolic Process NADP Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle)
Drugs		Isocitric Acid Enasidenib
Diseases
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Novel Interacting Genes		3 novel interacting genes: ACAN FURIN GPX1
Interacting Genes		3 interacting genes: FBXO7 PYGL SLC2A4
Entrez ID		3418
HPRD ID		00973
Ensembl ID		ENSG00000182054
Uniprot IDs		B4DSZ6 P48735
PDB IDs		4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6VFZ
Enriched GO Terms of Interacting Partners?
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