IDE and SLC28A2

Data Source:
BioGRID (affinity chromatography technology)

		IDE	SLC28A2
Description		insulin degrading enzyme	solute carrier family 28 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Coated Vesicle Brush Border Membrane
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Nucleoside:sodium Symporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Symporter Activity Pyrimidine- And Adenine-specific:sodium Symporter Activity Azole Transmembrane Transporter Activity
	Biological Process	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Retina Homeostasis Nucleobase-containing Compound Metabolic Process Neurotransmitter Transport Pyrimidine Nucleobase Transport Purine Nucleoside Transmembrane Transport Uridine Transport Adenosine Transport Inosine Transport Azole Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs		Insulin pork Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 32499647 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)	Estimated glomerular filtration rate ( 31015462) Uric acid levels ( 22229870) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5
Entrez ID		3416	9153
HPRD ID		00894	07069
Ensembl ID		ENSG00000119912	ENSG00000137860
Uniprot IDs		A0A3B3ISG5 B3KSB8 P14735	O43868 Q2M2A7 Q53H72
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
Enriched GO Terms of Interacting Partners?
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