RSPO2 and SLC39A7

Data Source:
BioGRID (two hybrid)

		RSPO2	SLC39A7
Description		R-spondin 2	solute carrier family 39 member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Cellular Zinc Ion Homeostasis Zinc Ion Transmembrane Transport
Pathways		Regulation of FZD by ubiquitination	Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		19 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 LGR4 LGR5 PLEKHF2 RNF43 SLC39A7 SUV39H1 ZNF330 ZNF837 ZNRF3	29 interacting genes: AQP6 BIK CLCA4 CRCT1 ERCC6 GJA8 KCNF1 KRTAP1-3 KRTAP5-7 KRTAP9-2 LCE1A LCE1C LCE1F LCE2C LCE2D LCE4A LCE5A LELP1 RGS17 RSPO2 SHISAL1 SLC34A2 SMCP SPRY3 TMEM14B TNFRSF10D UNC93A WFDC12 YY1
Entrez ID		340419	7922
HPRD ID		17536	09028
Ensembl ID		ENSG00000147655	ENSG00000112473
Uniprot IDs		B3KVP3 Q6UXX9	A0A024RCX7 B4DZZ8 Q92504
PDB IDs
Enriched GO Terms of Interacting Partners?
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