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KRTAP6-2 and CAMK2B
Data Source:
BioGRID
(two hybrid)
KRTAP6-2
CAMK2B
Description
keratin associated protein 6-2
calcium/calmodulin dependent protein kinase II beta
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Endocytic Vesicle Membrane
Sarcoplasmic Reticulum Membrane
Neuron Projection
Synapse
Molecular Function
Protein Binding
Identical Protein Binding
Actin Binding
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Keratinization
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Adaptation
Protein Autophosphorylation
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Synapse Structural Plasticity
Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Regulation Of Dendritic Spine Development
Positive Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Synapse Maturation
Regulation Of Cellular Response To Heat
Regulation Of Neuron Migration
Pathways
Keratinization
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Fostamatinib
Diseases
GWAS
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Intracranial aneurysm (
29531279
)
Metabolic syndrome (
22399527
)
Osteoarthritis (hip) (
23989986
)
Systolic blood pressure (
30578418
)
Triglyceride levels (
32203549
)
Interacting Genes
185 interacting genes:
ADAM12
ADAMTSL4
ANAPC11
ANKS1A
ANXA11
APOBEC1
AQP1
ARID5A
ATG9A
ATN1
ATPAF2
BEX2
BHLHE40
C10orf55
C1orf94
C20orf85
C6orf15
CAMK2A
CAMK2B
CASC3
CATSPER1
CCDC120
CCDC17
CCDC28A-AS1
CCER1
CCNK
CELF5
CERCAM
CERK
CFP
CHIC2
COL8A1
CREB5
CTRC
CYSRT1
DAZAP2
DHRS1
DMRT3
ENKD1
ESR2
FAAP20
FAM166B
FAM168A
FAM214B
FAM83A
FOXD2
FOXD4L1
FOXD4L3
FOXP3
FRS3
GALT
GATA3
GCM2
GLIS2
GLYCTK
GNE
GPS2
GRINA
GRN
GSTP1
HAPLN2
HELT
HEY1
HEY2
HEYL
HHEX
HOXA1
HOXB9
HOXC8
HOXC9
HSF4
HYAL2
IGFN1
INCA1
INO80B
ITGB4
KLHL38
KPRP
KRT83
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP15-1
KRTAP19-5
KRTAP26-1
KRTAP3-3
KRTAP4-11
KRTAP4-12
KRTAP6-1
KRTAP6-3
LASP1
LCE2B
LCE2D
LCE5A
LETM1
LGALS9C
LRFN4
LRRC41
LYVE1
MEIS2
MGAT5B
MKRN3
NAF1
NDUFA9
NEU4
NFKBID
NID2
NPBWR2
NR1D2
NSD1
OLIG3
OTX1
PATL1
PATZ1
PAX3
PDP1
PHLDA1
PITX1
PKD2
PLEKHN1
PLSCR4
POGZ
POU5F2
PPP1R32
PRR13
PRR3
PRR30
PRR35
RASD1
RBFOX2
RBPMS2
RERE
RHOXF2
RNF38
ROR2
RTP5
RUNX1T1
RUSC1
SAMD7
SHARPIN
SIAH3
SMAP2
SMARCC1
SMN1
SMN2
SMUG1
SNRPB
SNRPC
SPAG8
SPATA8
TBX6
TCF7L2
TEKT3
TEKT4
TEKT5
TENT5B
TENT5D
TEPSIN
TEX37
TFAP2D
TLE5
TLX2
TLX3
TNIP1
TOLLIP
TPRX1
TRIP13
TSGA10IP
TSPAN4
TSPYL6
VAC14
VENTX
VGLL3
VPS37C
YPEL3
ZBTB32
ZC3H10
ZIC1
ZNF414
ZNF503
ZNF581
ZNF683
ZNF843
56 interacting genes:
ACOT7
ACTN4
AP5B1
ARSA
ATXN1
CAMK2A
CAMK2D
CAMK2G
CAMK2N2
CCM2L
CDC37
COL4A3
DUS1L
ETS1
FAM171A2
GAPDH
GRIN2A
GRIN2B
ITPKA
KRT86
KRTAP1-1
KRTAP10-11
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
MAD2L2
MED18
MEOX2
MGAT5B
MORF4L1
MORF4L2
MRPL11
MVP
PHKB
PLCB3
PNKP
POLR3C
POP5
RAP2B
RBFOX2
RBPMS
RNF4
RPL11
RXRG
SEMA4G
SMYD3
SPRYD7
THRB
TNPO2
TNPO3
TTC5
YWHAB
ZBTB32
ZMYM5
Entrez ID
337967
816
HPRD ID
11219
12127
Ensembl ID
ENSG00000186930
ENSG00000058404
Uniprot IDs
Q3LI66
A4D2J9
B7Z1Z6
Q13554
PDB IDs
3BHH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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