METTL21A and MSRB3

Data Source:
BioGRID (two hybrid)

		METTL21A	MSRB3
Description		methyltransferase like 21A	methionine sulfoxide reductase B3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding	Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity
	Biological Process	Protein Methylation Peptidyl-lysine Methylation Regulation Of ATPase Activity	Response To Oxidative Stress Protein Repair
Pathways		Protein methylation	Protein repair
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)	Antisaccade task score ( 31596458) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		15 interacting genes: ARPC4 ATRIP HSPA1A HSPA5 HSPA8 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZBED8 ZNF620 ZNF655 ZRANB1	32 interacting genes: ASB13 BANP CTBP2 EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 WDR61 ZMYND12
Entrez ID		151194	253827
HPRD ID		14090	14785
Ensembl ID		ENSG00000144401	ENSG00000174099
Uniprot IDs		C9JES0 H7BXH9 Q8WXB1	Q8IXL7
PDB IDs		4LEC	6QA0
Enriched GO Terms of Interacting Partners?
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