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METTL21A and HSPA8
Data Source:
BioGRID
(enzymatic study)
METTL21A
HSPA8
Description
methyltransferase like 21A
heat shock protein family A (Hsp70) member 8
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Late Endosome
Autophagosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Dendrite
Secretory Granule Lumen
Melanosome
Terminal Bouton
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Photoreceptor Ribbon Synapse
Glycinergic Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Postsynaptic Specialization Membrane
Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Protein Methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Hsp70 Protein Binding
Heat Shock Protein Binding
ATPase Binding
G Protein-coupled Receptor Binding
Phosphatidylserine Binding
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Clathrin-uncoating ATPase Activity
Biological Process
Protein Methylation
Peptidyl-lysine Methylation
Regulation Of ATPase Activity
MRNA Splicing, Via Spliceosome
Protein Folding
Response To Unfolded Protein
Neurotransmitter Secretion
Cellular Response To Starvation
Viral Process
Vesicle-mediated Transport
Cytokine-mediated Signaling Pathway
Regulation Of Protein Stability
Cellular Response To Unfolded Protein
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Neutrophil Degranulation
Regulation Of MRNA Stability
Positive Regulation By Host Of Viral Genome Replication
Negative Regulation Of Transcription, DNA-templated
ATP Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Chaperone Cofactor-dependent Protein Refolding
Regulation Of Cell Cycle
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Late Endosomal Microautophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy
Clathrin Coat Disassembly
Regulation Of Postsynapse Organization
Regulation Of Cellular Response To Heat
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Slow Axonal Transport
Pathways
Protein methylation
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Opioid sensitivity (
23183491
)
Systolic blood pressure (
28135244
28739976
30578418
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Interacting Genes
15 interacting genes:
ARPC4
ATRIP
HSPA1A
HSPA5
HSPA8
LNX1
LZTS1
MEI4
MEOX2
MSRB3
PFDN5
ZBED8
ZNF620
ZNF655
ZRANB1
91 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CAPZA1
CAPZB
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DNAJB1
DPP3
DYNLL1
EGFR
ENO1
ERBB3
ERH
ESR1
FANCC
FBP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
METTL21A
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
SGTA
SIRPA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCAP
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
VHL
YWHAG
YWHAQ
Entrez ID
151194
3312
HPRD ID
14090
07205
Ensembl ID
ENSG00000144401
ENSG00000109971
Uniprot IDs
C9JES0
H7BXH9
Q8WXB1
P11142
Q53HF2
V9HW22
PDB IDs
4LEC
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
Enriched GO Terms of Interacting Partners
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