HOXC4 and RPRD1B

Data Source:
BioGRID (two hybrid)

		HOXC4	RPRD1B
Description		homeobox C4	regulation of nuclear pre-mRNA domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm RNA Polymerase II, Holoenzyme
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Complex Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development	Positive Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process MRNA 3'-end Processing SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878 27618447 30578418) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		17 interacting genes: APP CLK3 CSNK2A1 ELMOD2 EXOSC5 HTT NCK2 NSD3 PRKDC PRMT5 PRMT6 RCHY1 RNF32 RPRD1B SOX10 SUV39H1 XRCC6	19 interacting genes: BIN3 CDCA8 DDIT4L HMG20A HOXC4 NUTF2 PFDN6 PIP4K2B PSMB1 RASSF3 RPRD1A SPG21 STEEP1 TERF2 TNPO2 TUBGCP4 UBE2I VAX1 VPS37C
Entrez ID		3221	58490
HPRD ID		00860	08513
Ensembl ID		ENSG00000198353	ENSG00000101413
Uniprot IDs		A0A024RB51 P09017 Q86TF7	Q9NQG5
PDB IDs			4FLA 4FU3 4HFG 4NAD 4Q94 4Q96
Enriched GO Terms of Interacting Partners?
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