APBB1 and ELMO1

Data Source:
BioGRID (pull down, two hybrid)

		APBB1	ELMO1
Description		amyloid beta precursor protein binding family B member 1	engulfment and cell motility 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Proline-rich Region Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion	Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Malaria ( 31844061)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)
Interacting Genes		69 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ARF6 ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	10 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		322	9844
HPRD ID		04087	12102
Ensembl ID		ENSG00000166313	ENSG00000155849
Uniprot IDs		B7Z4M9 O00213	A4D1X5 Q92556
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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