HNRNPK and PRPF31

Data Source:
BioGRID (two hybrid)

		HNRNPK	PRPF31
Description		heterogeneous nuclear ribonucleoprotein K	pre-mRNA processing factor 31
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GO Annotations	Cellular Component	Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding SnRNP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II RNA Processing Signal Transduction Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Viral Process RNA Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Receptor Activity	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	mRNA Splicing - Major Pathway
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases			Retinitis pigmentosa (RP)
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglyceride levels ( 32203549)	Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)
Interacting Genes		220 interacting genes: ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BTRC C6orf223 C6orf226 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO7 FBXW7 FOXD4L1 FOXD4L3 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LYN MAP2K2 MAPK10 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF4 RPH3AL RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 U2AF1L5 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1	135 interacting genes: ASB15 BHLHB9 BICD2 C1QTNF1 CALCOCO2 CAPNS2 CARD14 CBY2 CCDC106 CCDC136 CCDC33 CCDC57 CCDC70 CCNDBP1 CDC23 CDCA7L CDR2L CEP70 CYSRT1 DVL2 DVL3 EFEMP2 EVI5 FANCA FANCC FASTK FLACC1 FSD2 FXR1 GOLGA2 GOLGA6L9 HAP1 HES7 HNRNPH2 HNRNPK HOOK2 HSF2BP JAKMIP2 KANK2 KCTD6 KHDRBS2 KHDRBS3 KIFC3 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP4-11 KRTAP6-3 LBX1 LDOC1 LHX8 LURAP1 LZTS2 MDFI MEIS3 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NCKIPSD NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PICK1 PLEKHG4 PNMA1 PNMA2 PNMA3 PPIH PPP1R16A PPP2R3C PRDM14 PRICKLE1 PRPF3 PSTPIP1 RACK1 RBAK RBM25 RBM4 RBMX RBMY1A1 RBMY1F RBMY1J REL RINT1 RUNDC3A SIAH1 SLAIN1 SNRNP200 SRSF3 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM14 TRIM23 TRIM27 TRIM41 TSGA10 UBXN11 USH1G USP15 VWC2 ZFP64 ZFP69B ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF48 ZNF587 ZNF668 ZNF71 ZNF774 ZNF792 ZNF837 ZRANB1 ZSCAN22
Entrez ID		3190	26121
HPRD ID		02834	05917
Ensembl ID		ENSG00000165119	ENSG00000105618
Uniprot IDs		B4DUQ1 P61978	Q8WWY3
PDB IDs		1J5K 1KHM 1ZZI 1ZZJ 1ZZK	2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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