MAVS and IRF5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MAVS	IRF5
Description		mitochondrial antiviral signaling protein	interferon regulatory factor 5
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane	Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity CARD Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization	Immune System Process Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Primary biliary cholangitis ( 21399635 20639880 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 21156761 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26663301 23053960 26502338 18204098 21408207 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 21750679 31672989 30572963 20383147 30247649 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 28067908 26398853 23128233 21297633)
Interacting Genes		20 interacting genes: ABL1 DDX3X DDX58 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 OTUD4 RIPK2 RNF34 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF6 UBE4A	17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1
Entrez ID		57506	3663
HPRD ID		13847	06240
Ensembl ID		ENSG00000088888	ENSG00000128604
Uniprot IDs		Q7Z434	A0A0G2USB5 B7Z1M2 C9JAU6 Q13568
PDB IDs		2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK	3DSH
Enriched GO Terms of Interacting Partners?
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