HCRTR1 and HCRT

Data Source:
HPRD (in vitro, in vivo)

		HCRTR1	HCRT
Description		hypocretin receptor 1	hypocretin neuropeptide precursor
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding	Neuropeptide Hormone Activity Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade	Temperature Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Suvorexant Lemborexant	Pidolic acid
Diseases
GWAS		Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566)
Interacting Genes		4 interacting genes: ARRB1 ARRB2 CNR1 HCRT	3 interacting genes: HCRTR1 HCRTR2 NPFFR2
Entrez ID		3061	3060
HPRD ID		03863	03836
Ensembl ID		ENSG00000121764	ENSG00000161610
Uniprot IDs		A6NMV7 O43613	O43612
PDB IDs		4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S	1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?
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