SERPIND1 and ELANE

Data Source:
HPRD (in vivo, in vitro)

		SERPIND1	ELANE
Description		serpin family D member 1	elastase, neutrophil expressed
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Antimicrobial Humoral Response Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade
Drugs		Ardeparin Zinc Sulodexide Copper Bemiparin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin
Diseases		Inherited thrombophilia	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS			Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: APP CTSG ELANE F2	30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		3053	1991
HPRD ID		00795	00554
Ensembl ID		ENSG00000099937	ENSG00000197561
Uniprot IDs		P05546 Q8IVC0	P08246
PDB IDs		1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK
Enriched GO Terms of Interacting Partners?
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