ELANE and YARS1

Data Source:
HPRD (in vitro)

		ELANE	YARS1
Description		elastase, neutrophil expressed	tyrosyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Nuclear Body
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	TRNA Binding RNA Binding Tyrosine-tRNA Ligase Activity Interleukin-8 Receptor Binding Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Antimicrobial Humoral Response Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	TRNA Aminoacylation For Protein Translation Tyrosyl-tRNA Aminoacylation Apoptotic Process
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade	Cytosolic tRNA aminoacylation
Drugs		Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin	Tyrosine Beta-(2-Naphthyl)-Alanine Resveratrol Tyrosinal N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE p-Benzoyl-L-phenylalanine 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	4 interacting genes: CDC42 ELANE ESR1 REL
Entrez ID		1991	8565
HPRD ID		00554	09153
Ensembl ID		ENSG00000197561	ENSG00000134684
Uniprot IDs		P08246	A0A0S2Z4R1 P54577
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK	1N3L 1NTG 1Q11 4Q93 4QBT 5THH 5THL
Enriched GO Terms of Interacting Partners?
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