SERPIND1 and CTSG

Data Source:
HPRD (in vitro)

		SERPIND1	CTSG
Description		serpin family D member 1	cathepsin G
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs		Ardeparin Zinc Sulodexide Copper Bemiparin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases		Inherited thrombophilia
GWAS			Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		4 interacting genes: APP CTSG ELANE F2	30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		3053	1511
HPRD ID		00795	00289
Ensembl ID		ENSG00000099937	ENSG00000100448
Uniprot IDs		P05546 Q8IVC0	P08311
PDB IDs		1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV	1AU8 1CGH 1KYN 1T32 6VTM
Enriched GO Terms of Interacting Partners?
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