HBG2 and SMAD5

Data Source:
HPRD (two hybrid)

		HBG2	SMAD5
Description		hemoglobin subunit gamma 2	SMAD family member 5
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GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Peroxidase Activity Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Hemoglobin Alpha Binding Organic Acid Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Blood Coagulation Oxygen Transport Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by BMP
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Malate levels ( 31560688) Mean corpuscular hemoglobin concentration ( 32888494 28453575) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		10 interacting genes: APP CYB5R3 HBA1 HBA2 HBB HBM HBQ1 RPSA SMAD5 XPNPEP1	46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID		3048	4090
HPRD ID		00792	04381
Ensembl ID		ENSG00000196565	ENSG00000113658
Uniprot IDs		D9YZU9 P69892	Q68DB7 Q99717
PDB IDs		1FDH 4MQJ 4MQK	6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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