ERO1A and PELI2

Data Source:
BioGRID (two hybrid)

		ERO1A	PELI2
Description		endoplasmic reticulum oxidoreductase 1 alpha	pellino E3 ubiquitin protein ligase family member 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Dendrite Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Folding Cellular Protein Modification Process Response To Temperature Stimulus Animal Organ Senescence Protein Phosphopantetheinylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Brown Fat Cell Differentiation Chaperone Cofactor-dependent Protein Refolding Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		Insulin processing Detoxification of Reactive Oxygen Species	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Urine 6-bromotryptophan levels in chronic kidney disease ( 32572055)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		12 interacting genes: APPBP2 EBF1 ERP44 GPX7 GPX8 LHX4 LINC01554 P4HB PDIA3 PDILT PELI2 RHOU	34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4
Entrez ID		30001	57161
HPRD ID		13278	17835
Ensembl ID		ENSG00000197930	ENSG00000139946
Uniprot IDs		Q96HE7	Q9H716 Q9HAT8
PDB IDs		3AHQ 3AHR	3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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