PELI2 and SEPTIN3

Data Source:
BioGRID (two hybrid)

		PELI2	SEPTIN3
Description		pellino E3 ubiquitin protein ligase family member 2	septin 3
Image
GO Annotations	Cellular Component	Cytosol	Septin Ring Microtubule Cytoskeleton Septin Complex Cell Division Site Neuron Projection Presynapse Presynaptic Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Molecular_function GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Cellular Protein Localization Cytoskeleton-dependent Cytokinesis
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4	18 interacting genes: CDC37 CHRM3 CKS1B DDIT4L EIF6 LASP1 MAPK6 MOB1A NTAQ1 PELI2 PRKG1 RNF4 RNF8 SDCBP SELENOF SEPTIN1 SLC39A14 WBP2
Entrez ID		57161	55964
HPRD ID		17835	10515
Ensembl ID		ENSG00000139946	ENSG00000100167
Uniprot IDs		Q9H716 Q9HAT8	Q9UH03
PDB IDs		3EGA 3EGB	3SOP 4Z51 4Z54 6UQQ
Enriched GO Terms of Interacting Partners?
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