GUCY1A1 and AGAP1

Data Source:
HPRD (two hybrid, in vivo)

		GUCY1A1	AGAP1
Description		guanylate cyclase 1 soluble subunit alpha 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Guanylate Cyclase Complex, Soluble Glutamatergic Synapse GABA-ergic Synapse	Nucleus Cytoplasm
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Positive Regulation Of Nitric Oxide Mediated Signal Transduction Relaxation Of Vascular Associated Smooth Muscle Retrograde Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission	Protein Transport Positive Regulation Of GTPase Activity
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs
Diseases
GWAS			Adult body size ( 32376654) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		4 interacting genes: AGAP1 IKBKG MAPK8 STUB1	14 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 ZNF534
Entrez ID		2982	116987
HPRD ID		00768	16359
Ensembl ID		ENSG00000164116	ENSG00000157985
Uniprot IDs		B3KU69 Q02108	B2RZG9 Q9UPQ3 X5D293
PDB IDs		3UVJ 4NI2 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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