AGAP1 and GUCY1B1

Data Source:
HPRD (two hybrid, in vivo)

		AGAP1	GUCY1B1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	guanylate cyclase 1 soluble subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Guanylate Cyclase Complex, Soluble Presynaptic Active Zone
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation CGMP-mediated Signaling Nitric Oxide-cGMP-mediated Signaling Pathway Cellular Response To Nitric Oxide Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission
Pathways			Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		14 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 ZNF534	4 interacting genes: AGAP1 APP GUCY1A2 HSP90AA1
Entrez ID		116987	2983
HPRD ID		16359	00769
Ensembl ID		ENSG00000157985	ENSG00000061918
Uniprot IDs		B2RZG9 Q9UPQ3 X5D293	B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153
PDB IDs			2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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