PDIA3 and SLC12A3

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		PDIA3	SLC12A3
Description		protein disulfide isomerase family A member 3	solute carrier family 12 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding	Protein Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Phosphopantetheinylation Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Triglyceride levels ( 32203549)	HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) Phoneme awareness ( 30741946)
Interacting Genes		21 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 GYPC HLA-A IFNG LGALS9 LINC01554 MDM2 MTNR1B PCAT1 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	2 interacting genes: PDIA3 WNK4
Entrez ID		2923	6559
HPRD ID		03625	02984
Ensembl ID		ENSG00000167004	ENSG00000070915
Uniprot IDs		P30101 V9HVY3	J3QSS1 P55017
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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