SLC12A3 and WNK4

Data Source:
HPRD (in vivo)

		SLC12A3	WNK4
Description		solute carrier family 12 member 3	WNK lysine deficient protein kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Bicellular Tight Junction Membrane
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)	Stimuli-sensing channels
Drugs		Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) Phoneme awareness ( 30741946)
Interacting Genes		2 interacting genes: PDIA3 WNK4	11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39
Entrez ID		6559	65266
HPRD ID		02984	03505
Ensembl ID		ENSG00000070915	ENSG00000126562
Uniprot IDs		J3QSS1 P55017	Q96J92
PDB IDs			2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?
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