DBNL and ACD

Data Source:
BioGRID (two hybrid)

		DBNL	ACD
Description		drebrin like	ACD shelterin complex subunit and telomerase recruitment factor
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GO Annotations	Cellular Component	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Perikaryon Postsynaptic Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Adaptive Immune Response Receptor-mediated Endocytosis Activation Of JUN Kinase Activity Synapse Assembly Rac Protein Signal Transduction Regulation Of Actin Filament Polymerization Neutrophil Degranulation Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Podosome Assembly Ruffle Assembly Postsynaptic Actin Cytoskeleton Organization	Telomere Maintenance Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 POT1 SH2D4A SH3BP2 SYK TERF1 TERF2IP ZAP70	63 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		28988	65057
HPRD ID		06588	12417
Ensembl ID		ENSG00000136279	ENSG00000102977
Uniprot IDs		B4DUF9 Q9UJU6	A0A590TQL1 Q96AP0
PDB IDs		1X67	2I46 5H65 5I2X 5I2Y 5UN7 5XYF
Enriched GO Terms of Interacting Partners?
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