DBNL and SH3BP2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		DBNL	SH3BP2
Description		drebrin like	SH3 domain binding protein 2
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GO Annotations	Cellular Component	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Perikaryon Postsynaptic Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding
	Biological Process	Adaptive Immune Response Receptor-mediated Endocytosis Activation Of JUN Kinase Activity Synapse Assembly Rac Protein Signal Transduction Regulation Of Actin Filament Polymerization Neutrophil Degranulation Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Podosome Assembly Ruffle Assembly Postsynaptic Actin Cytoskeleton Organization	Signal Transduction
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs
Diseases			Cherubism
GWAS		Blood protein levels ( 30072576)	Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		12 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 POT1 SH2D4A SH3BP2 SYK TERF1 TERF2IP ZAP70	31 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		28988	6452
HPRD ID		06588	03657
Ensembl ID		ENSG00000136279	ENSG00000087266
Uniprot IDs		B4DUF9 Q9UJU6	A0A384N6E5 P78314
PDB IDs		1X67	2CR4 3TWR
Enriched GO Terms of Interacting Partners?
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