GPX1 and CISH

Data Source:
BioGRID (affinity chromatography technology)

		GPX1	CISH
Description		glutathione peroxidase 1	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: ABL1 ABL2 FAM9B MAPK6 SELENBP1	17 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		2876	1154
HPRD ID		11749	03897
Ensembl ID		ENSG00000233276	ENSG00000114737
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	Q9NSE2
PDB IDs		2F8A
Enriched GO Terms of Interacting Partners?
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