CISH and IL3RA

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CISH	IL3RA
Description		cytokine inducible SH2 containing protein	interleukin 3 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs			Sargramostim Tagraxofusp
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Schizophrenia ( 17522711)
Interacting Genes		17 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5
Entrez ID		1154	3563
HPRD ID		03897	02392
Ensembl ID		ENSG00000114737	ENSG00000185291
Uniprot IDs		Q9NSE2	P26951
PDB IDs			4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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