KCTD1 and EXOSC1

Data Source:
BioGRID (two hybrid)

		KCTD1	EXOSC1
Description		potassium channel tetramerization domain containing 1	exosome component 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Centriolar Satellite Intercellular Bridge	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Negative regulation of activity of TFAP2 (AP-2) family transcription factors	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Sudden cardiac arrest ( 21658281)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		19 interacting genes: EPM2AIP1 EXOSC1 KCTD15 LMO1 LMO3 LNX1 MORF4L2 NTAQ1 PICK1 POLR1C PRKAA2 PSMA1 SDCBP TGM7 TRAPPC2 TRAPPC2B UBASH3A UBE2I ZBTB25	34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76
Entrez ID		284252	51013
HPRD ID		11059	16223
Ensembl ID		ENSG00000134504	ENSG00000171311
Uniprot IDs		A0A024RC45 A0A2U3U043 Q719H9	B1AMU3 Q9Y3B2
PDB IDs		5BXB 5BXD 6S4L	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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