NEK8 and NEK9

Data Source:
BioGRID (enzymatic study)

		NEK8	NEK9
Description		NIMA related kinase 8	NIMA related kinase 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cilium Ciliary Inversin Compartment Ciliary Base	Nucleus Centrosome Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Chromosome Segregation Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways			Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		11 interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		284086	91754
HPRD ID		14822	11386
Ensembl ID		ENSG00000160602	ENSG00000119638
Uniprot IDs		Q86SG6	Q6PKF2 Q8TD19
PDB IDs			3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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