GOT2 and BBS2

Data Source:
BioGRID (genetic interference)

		GOT2	BBS2
Description		glutamic-oxaloacetic transaminase 2	Bardet-Biedl syndrome 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface T-tubule Protein-containing Complex Perikaryon Extracellular Exosome	Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane
	Molecular Function	RNA Binding L-aspartate:2-oxoglutarate Aminotransferase Activity Phospholipid Binding Kynurenine-oxoglutarate Transaminase Activity Amino Acid Binding Enzyme Binding Pyridoxal Phosphate Binding Identical Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Female Pregnancy Lactation Cellular Amino Acid Biosynthetic Process Response To Muscle Activity Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Response To Insulin Response To Morphine Response To Ethanol Glyoxylate Metabolic Process L-kynurenine Metabolic Process	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Gluconeogenesis Aspartate and asparagine metabolism Glutamate and glutamine metabolism	BBSome-mediated cargo-targeting to cilium
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Aortic root size ( 21223598) Aspartate aminotransferase levels ( 29403010) Automobile speeding propensity ( 30643258) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6	15 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PSME3 RBPMS
Entrez ID		2806	583
HPRD ID		00684	05855
Ensembl ID		ENSG00000125166	ENSG00000125124
Uniprot IDs		P00505	Q9BXC9
PDB IDs		5AX8
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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